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应用LSAB免疫组织化学染色方法,对40例乳腺癌标本nm23表达产物核苷二磷酸激酶(NDPK)进行了测定,结果表明:NDPK/nm23在乳腺癌中的表达率显著高于癌旁正常组织(P<0.01)。NDPK/nm23表达与乳腺癌组织的分化程度及腋窝淋巴结转移密切相关(P<0.05)。NDPK/nm23阳性患者与阴性患者的5年生存率有显著性差别(P<0.05),提示NDPK/nm23的检测,对于指导术后进一步治疗、预后的判断有重要临床意义。
NDAB immunohistochemical staining was used to detect the expression of nucleoside diphosphate kinase (NDPK), a product of nm23 expression in 40 breast cancer specimens. The results showed that the expression rate of NDPK/nm23 in breast cancer was significantly higher than that in adjacent normal tissues. P<0.01). The expression of NDPK/nm23 was closely related to the differentiation of breast cancer tissues and the metastasis of axillary lymph nodes (P<0.05). The 5-year survival rate of NDPK/nm23 positive and negative patients was significantly different (P<0.05), suggesting that the detection of NDPK/nm23 has important clinical significance for guiding postoperative further treatment and prognosis.