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目的探讨Ⅱ型糖尿病患者中并发糖尿病肾病和无并发肾病患者的脂代谢变化特点。方法将130例Ⅱ型糖尿病患者根据尿白蛋白排泄率(UAER)分为3组:无DN组(UAER<20μg/min)45例;DN组85例,其中微量白蛋白尿期组(UAER为20-200μg/min)42例,临床白蛋白尿期组(UAER>200μg/min)43例。测定空腹血糖(FBG)、糖化血红蛋白、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB),并与正常对照组比较。结果 DN组病程、TG、LDL-c、ApoB明显高于非DN组,差异有统计学意义(P<0.01);两组TC、HDL-c、ApoA1差异无统计学意义(P>0.05);DN组的FBG和糖化血红蛋白高于非DN组,但差异无统计学意义(P>0.05)。结论Ⅱ型糖尿病患者脂代谢紊乱越明显,病程越长,DN发生机会越多。
Objective To investigate the changes of lipid metabolism in type 2 diabetic patients with and without diabetic nephropathy. Methods One hundred and thirty patients with type Ⅱ diabetes were divided into three groups according to the urinary albumin excretion rate (UAER): 45 cases without DN (UAER <20μg / min); 85 cases with DN (microalbuminuria group 42 cases were in the range of 20-200μg / min and 43 cases were in the albuminuria group (UAER> 200μg / min). Fasting blood glucose (FBG), HbA1c, TC, TG, HDL-c, LDL-c, ApoA1), apolipoprotein B (ApoB), and compared with the normal control group. Results The course of disease, TG, LDL-c and ApoB in DN group were significantly higher than those in non-DN group (P <0.01). There was no significant difference in TC, HDL-c and ApoA1 between the two groups (P> 0.05). DN group FBG and HbA1c than non-DN group, but the difference was not statistically significant (P> 0.05). Conclusions Patients with type II diabetes have more obvious lipid metabolism disorder. The longer the course of disease, the more chance of DN occurrence.