论文部分内容阅读
目的：探讨转化生长因子－β１（ＴＧＦ－β１）在肾细胞癌中的表达部位和程度以及与临床指标间的关系。方法：应用抗ＴＧＦ－β１多克隆抗体对４３例肾细胞癌进行免疫组化研究（同时取１０例尸检正常肾组织作为对照）。结果：ＴＧＦ－β１在肾癌组织中表达阳性率８６．１％（３７／４３），明显高于正常肾组织（Ｐ＜０．００５）；表达强度与术中见有无周围组织侵袭有相关性（Ｐ＜０．０５），与肿瘤大小无关。结论：ＴＧＦ－β１表达是肾癌的恶性表型之一，对评估肾癌的预后有重要意义。
Objective: To investigate the expression of transforming growth factor-β1 (TGF-β1) in renal cell carcinoma and its relationship with clinical parameters. Methods: 43 cases of renal cell carcinoma were studied by immunohistochemistry with anti-TGF-β1 polyclonal antibody (10 cases of normal renal tissue were taken as control). Results: The positive rate of TGF-β1 in renal cell carcinoma was 86.1% (37/43), which was significantly higher than that in normal renal tissues (P <0.005). The expression of TGF-β1 was correlated with the presence or absence of surrounding tissue invasion (P <0.05), but not with tumor size. Conclusion: The expression of TGF-β1 is one of the malignant phenotypes of renal cell carcinoma, which is of great significance for evaluating the prognosis of renal cell carcinoma.