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目的 探讨幽门螺杆菌 (HP)与活动性十二指肠溃疡治愈及复发的关系。方法 将活动性十二指肠溃疡患者随机分为观察组 46例和对照组 40例 ,分别采用奥美拉唑联合呋喃唑酮治疗和单用奥美拉唑治疗进行效果对比。结果 观察组和对照组的治愈率分别为 95 .6 %和 80 % (P <0 .0 5 ) ,HP根除率分别为 97.72 %和 2 8.12 % (P <0 .0 1) ,未复发率分别为 95 .45 %和 2 1.87% (P <0 .0 1)。结论 根除HP是治愈溃疡及防止复发的有力措施 ,奥美拉唑和呋喃唑酮合用根除HP是很有效的方法之一。
Objective To investigate the relationship between Helicobacter pylori (HP) and active duodenal ulcer healing and recurrence. Methods The patients with active duodenal ulcer were randomly divided into observation group (46 cases) and control group (40 cases). The effects of omeprazole combined with furazolidone and omeprazole alone were compared. Results The cure rates of the observation group and the control group were 95.6% and 80%, respectively (P <0.05), and the eradication rates of HP were 97.72% and 2.12% (P <0.01) respectively, with no recurrence rate 95.45% and 2.87% respectively (P <0.01). Conclusions Eradication of HP is a powerful measure to cure ulcer and prevent recurrence. Combination of omeprazole and furazolidone to eradicate HP is one of the most effective methods.