结直肠癌术后5年生存率仅为50%～55%,其主要原因是结直肠癌的转移,而最常见、最易发生的是肝转移。结直肠癌肝转移是一复杂而连续的过程,首先癌细胞由运动因子启动,降解胞外基质脱离原发灶进入门静脉,随后通过信号传导,在相关受体和因子的作用下到达肝脏,穿出血管重新黏附,进而 The 5-year survival rate of colorectal cancer after surgery is only 50% to 55%, the main reason is the metastasis of colorectal cancer, and the most common and most prone to liver metastasis. Liver metastasis of colorectal cancer is a complex and continuous process. First, cancer cells are activated by motor factors, which degrade the extracellular matrix from the primary tumor and enter the portal vein, and then reach the liver through signaling and related receptors and factors Re-adhesion of the vessel, and then