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目的：观察去卵巢骨质疏松症大鼠骨密度及血清钙磷含量，探讨绝经后骨质疏松症的发病机制以及补肾中药复方的作用机制。方法麻醉状态下手术摘除卵巢复制骨质疏松症大鼠模型，实验设正常对照组、模型对照组、假手术对照组、补肾中药复方组、钙尔奇D组、骨疏康组，灌胃给药12w。应用骨密度仪测定股骨骨密度，检测血清钙、磷含量。结果与正常对照组比较，模型对照组股骨骨密度明显降低。与模型对照组比较，补肾中药复方组股骨骨密度明显升高，血清钙、磷含量明显升高。结论手术摘除卵巢大鼠12w后可出现骨质疏松症，补肾中药复方具有明显的防治作用，其作用机制与提高血清钙磷含量密切相关。“,”Objective To observe the bone mineral density and the serum calcium and phosphorus of ovariectomized osteoporosis rats.to discuss the pathogenesis of postmenopausal osteoporosis(PMOP) and the therapeutic ef ect and mechanism of reinforcing the kidney traditional Chinese herbs compound.Methods To establishe the osteoporosis rat models by ovariectomy.Al the rats were divided into the normal group,the model group,the sham operated group,the reinforcing the kidney traditional Chinese herbs compound group,the GAIERQI D group and the GUSHUKANG group.After 12 weeks of administrating by gavage,we detected the femur bone mineral density and the serum calcium and phosphorus contents. Results Compared with normal group,femur bone mineral density of model group decreased significantly. Compared with the model group, the reinforcing the kidney traditional Chinese herbs compound group the femur bone mineral density, the serum calcium and phosphorus content increased significantly. Conclusion The ovariectomized rats after 12 weeks can appear osteoporosis.The reinforcing the kidney traditional Chinese herbs compound has obvious preventing and treating ef ect. The mechanism is closely related with improve the contents of serum calcium and phosphorus.