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胰酶主要用于胰腺外分泌功能不足的病人,如囊性纤维化、胰切除术后、全胃切除术后以及慢性胰腺炎。该文作者就胰酶的替代治疗作如下综述,主要包括胰腺外分泌功能的评估,胰腺外分泌不足的发病机制,胰酶制剂的多种形式及其疗效,胰酶使用的剂量,肠内营养与胰酶替代治疗的关系以及使用胰酶的不良反应等。
Pancreatin is mainly used in patients with pancreatic exocrine insufficiency, such as cystic fibrosis, pancreatic resection, total gastrectomy and chronic pancreatitis. The authors review the pancreatic enzyme replacement therapy as follows, including the assessment of pancreatic exocrine function, the pathogenesis of pancreatic exocrine insufficiency, various forms of pancreatic enzyme preparations and their efficacy, the dose of pancreatin used, the concentration of enteral nutrition and pancreatic juice Enzyme replacement therapy and the use of trypsin adverse reactions.