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目的:探讨局部晚期宫颈癌术前介入化疗的疗效及对VEGF的表达。方法:评定47例局部晚期宫颈癌介入化疗效果并应用RT-PCR方法测定化疗前后组织中VEGF表达化疗近期。结果:介入栓塞化疗的总有效率87.2%,ⅠB2期、ⅡA期、ⅡB期宫颈癌介入化疗效果无明显差异(P>0.05),ⅢA期及ⅢB期宫颈癌介入治疗效果无明显差异(P>0.05)且治疗有效率明显低于前三组(P<0.05),治疗前局部晚期宫颈癌组织中VEGF的表达与肿瘤的临床分期、淋巴结转移、病理类型、组织学分级均明显相关(P<0.05);介入治疗后高分化宫颈癌及无淋巴结转移的宫颈癌中VEGF表达无明显下降(P>0.05);不同临床分期、有淋巴结转移、不同病理类型及中、低分化的局部晚期宫颈癌介入治疗后VEGF表达均明显降低(P<0.05)。结论:术前介入栓塞化疗对局部晚期宫颈癌有良好近期效果,是一种可行、有效的辅助治疗手段。VEGF可作为判断治疗效果的指标。
Objective: To investigate the curative effect of preoperative chemotherapy and the expression of VEGF on locally advanced cervical cancer. Methods: Forty-seven patients with locally advanced cervical cancer were included in the study. The chemotherapeutic effect of VEGF was evaluated by RT-PCR before and after chemotherapy. Results: The total effective rate of interventional chemotherapy was 87.2%. There was no significant difference in interventional chemotherapy between stage ⅠB2, stage ⅡA and stage ⅡB cervical cancer (P> 0.05), while there was no significant difference between stage ⅢA and stage ⅢB cervical cancer intervention (P> 0.05), and the treatment efficiency was significantly lower than the first three groups (P <0.05). The expression of VEGF in locally advanced cervical cancer tissues was significantly correlated with the clinical stage, lymph node metastasis, pathological type and histological grade (P < 0.05). There was no significant difference in VEGF expression between well-differentiated cervical cancer and cervical cancer without lymph node metastasis after interventional therapy (P> 0.05). There were different clinical stages, lymph node metastasis, different pathological types and moderate and poorly differentiated locally advanced cervical cancer After intervention, VEGF expression was significantly decreased (P <0.05). Conclusion: Preoperative interventional chemoembolization has good immediate effect on locally advanced cervical cancer, which is a feasible and effective adjuvant therapy. VEGF can be used as an indicator of the therapeutic effect.