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烟草的烟雾中含有许多致癌物,如4-甲基亚硝胺-1-(3-吡啶)-1-丁酮(NNK)和 N′-亚硝基去甲烟碱(NNN)等,可诱发烟草相关肿瘤。吸烟和吸鼻烟者接触 NNK 和 NNN 的剂量与其使动物致癌的剂量相近,无论何种途径给药,
Tobacco smoke contains many carcinogens such as 4-methylnitrosamine-1 (3-pyridine) -1-butanone (NNK) and N’- nitrosonitro-nicotine Induced tobacco-related tumors. Smoking and sniffing exposure to NNK and NNN dose and its animal carcinogenic dose similar regardless of the route of administration,