编者按到目前为止已超过2000种神经保护性药物临床前期试验失败。为此,开发用于缺血性卒中治疗的新药物、新靶点是一项亟待解决的工作。整体动物模型比较接近于脑缺血病理状态,但是实验动物的个体差异,实验人员的技术水平等,对实验结果容易造成影响。而利用细胞模型则可以克服动物模型的不足,并根据脑缺血病理生理机制中的不同进程,从不同角度选用不同类型的细胞模型,对研究缺血性卒中的发病机制及大规模筛选药 The editor has so far failed the preclinical trial of more than 2,000 neuroprotective drugs. To this end, the development of new drugs for ischemic stroke treatment, a new target is a work to be solved. The overall animal model is relatively close to the pathological state of cerebral ischemia, but individual differences in experimental animals, the experimental level of technical personnel, the experimental results easily affect. The use of cell model can overcome the deficiencies of animal models, and according to different pathological and physiological mechanisms of cerebral ischemia, different types of cell models from different angles, the study of the pathogenesis of ischemic stroke and large-scale screening of drugs