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目的研究并分析慢性心力衰竭患者外周血清糖类抗原CA125水平与心力衰竭定量标志物-脑利钠肽(BNP)水平及心功能的相关性。方法根据NYHA心功能分级标准将100例慢性心力衰竭患者分为Ⅰ-Ⅱ级组、Ⅲ组级、Ⅳ级组3组,比较各组间CA125水平、BNP水平、左室射血分数(LVEF),并分析CA125水平与BNP水平、左室射血分数(LVEF)、左室舒末内径(LVEDD)、左心房内径(LA)的相关性。结果(1)各组间CA125水平、BNP水平、LVEF比较结果如下:Ⅲ级组CA125水平、BNP水平、LVEF均显著高于Ⅰ-Ⅱ级组;Ⅳ级组CA125水平、BNP水平、LVEF均显著高于Ⅰ-Ⅱ级组;Ⅳ级组CA125水平、BNP水平、LVEF均显著高于Ⅲ级组,差异均有统计学意义(P<0.05)。(2)CA125水平与BNP水平、LVEDD、LA呈正相关性,与LVEF呈负相关性。结论糖类抗原CA125与慢性心力衰竭的严重程度有关,可作为判断和评价慢性心力衰竭的又一有价值的指标,但仍需进一步研究,以便在临床上推广应用。
Objective To study and analyze the correlation between serum CA125 level in patients with chronic heart failure and the level of quantitative brain natriuretic peptide (BNP) and cardiac function in patients with heart failure. Methods One hundred patients with chronic heart failure were divided into three groups according to the New York Heart Association grading criteria: group Ⅰ-Ⅱ, group Ⅲ and group Ⅳ. The levels of CA125, BNP, LVEF, . The correlation between CA125 level and BNP level, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), and left atrium diameter (LA) were analyzed. Results (1) The levels of CA125, BNP and LVEF in each group were as follows: The levels of CA125, BNP and LVEF in group Ⅲ were significantly higher than those in group Ⅰ-Ⅱ; The levels of CA125, BNP and LVEF in group Ⅳ were significantly The level of CA125, the level of BNP and the level of LVEF in grade Ⅳ were significantly higher than those in grade Ⅲ, the difference was statistically significant (P <0.05). (2) The level of CA125 was positively correlated with BNP level, LVEDD and LA, but negatively correlated with LVEF. Conclusion The carbohydrate antigen CA125 is related to the severity of chronic heart failure and can be used as another valuable index for judging and evaluating chronic heart failure. However, further study is needed to promote its application in clinic.