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目的了解河南省既往有偿采供血感染艾滋病病毒(HIV)人群的生存时间及影响因素。方法采用回顾性队列研究方法,对河南省两乡镇1998-2007年既往有偿采供血感染HIV者529例进行调查,采用Cox风险比例模型分析影响感染HIV者生存时间的因素。结果感染HIV人群平均生存时间为9.98年(95%CI:9.83~10.13),1998年及以前、1999-2000年、2001-2003年、2004年及以后,发展为AIDS病人平均生存时间和95%可信区间分别为4.00年(95%CI:3.33~4.67)、6.73年(95%CI:6.21~7.25)、9.63年(95%CI:9.39~9.86)、10.86年(95%CI:10.80~10.92);相对于接受高效抗逆转录病毒治疗(HAART)者,未接受HAART治疗者的生存概率仅为0.22(RR95%CI:0.15~0.33)。结论AIDS发病时间和是否接受HAART治疗,是影响河南省既往有偿采供血地区感染HIV人群生存时间的主要因素。
Objective To understand the survival time and influential factors of previous paid-for-blood-infected people living with HIV in Henan Province. Methods A retrospective cohort study was conducted to investigate the prevalence of 529 HIV-infected individuals in two villages in Henan Province during 1998-2007. The Cox risk proportional model was used to analyze the factors influencing the survival time of those infected with HIV. Results The average survival time of AIDS patients was 9.88 years (95% CI: 9.83-10.13), the average survival time of AIDS patients in 1998 and before, 1999-2000, 2001-2003, 2004 and later, and 95% The confidence interval was 4.00 years (95% CI: 3.33-4.67), 6.33 years (95% CI: 6.21-7.25), 9.33 years (95% CI: 9.39-9.86) and 10.86 years (95% CI: 10.92). The survival rate of non-HAART patients was only 0.22 (RR95% CI: 0.15-0.33) relative to those who received HAART. Conclusion The onset time of AIDS and whether or not HAART is treated are the main factors that affect the survival time of HIV-infected people in Henan Province in the past paid areas for blood supply.