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以2种糖醇(山梨醇和木糖醇)的共晶为原料,采用原位包衣技术制备儿科用对乙酰氨基酚(PCT)锭剂。与常规压片工艺相比,这种类型的熔融技术更具成本-效益效应,也更简单。该锭剂的成型和包衣发生在同一制造步骤中,再通过1个冷却步骤使生产的锭剂具有较软的内芯和较硬且有抗性的外壳。在含有PCT的共晶中加入聚乙二醇(PEG)2000或PEG 6000,可相当大程度地提高PCT的溶出速率。尤其是加入PEG 2000时,
Paracetamol acetaminophen (PCT) tablets were prepared by in situ coating using eutectic of two sugar alcohols (sorbitol and xylitol) as raw materials. This type of melting technology is more cost-effective and easier than conventional tableting. The shaping and coating of the pastilles takes place in one and the same manufacturing step, with the pastilles produced having a softer inner core and a harder and more resistant outer shell through one cooling step. The addition of polyethylene glycol (PEG) 2000 or PEG 6000 to PCT-containing eutectics can considerably improve the dissolution rate of PCT. Especially when adding PEG 2000,