目的 为比较不同人工关节微小磨损颗粒对假体－ 骨界面处骨整合及骨溶解的影响,探明假体松动的机制.方法 本实验采用扫描电镜技术对钛合金(TI6AL4V)、钴－ 铬－ 钼(COCRMO)与聚乙烯(ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE,UHMWPE)三种微小颗粒诱导的假体周围骨组织改变进行超微结构观察.结果 研究发现,直径2.5 ΜM 的TI6AL4V 颗粒诱导置入物旁骨吸收或骨溶解的程度明显低于相同直径的COCRMO 颗粒或UHMWPE 颗粒.结论 TI6AL4V、COCRMO 或UHMWPE颗粒可不同程度地影响假体－ 骨界面处骨整合, COCRMO 或UHMWPE 颗粒似乎具有更强的诱导置入物松动形成作用.“,”Objective To compare the effects of various kinds of micron-sized wear particles on osteointegration at implant-bone interface and process of periimplant osteolysis, to delineate the mechanism of aseptic loosening of artificial joint. Methods Three special particles of ultra high molecular weight polyethylene(UHMWPE), Ti 6Al 4V and Co Cr Mo were used respectively to induce the change of periimplant bone structure of a well fixed implant made of titanium alloy in rabbit femur or tibia. The bone structure at implant-bone interface was observed by scanning electron microscope(SEM). Results Ti 6Al 4V particle induced less periimplant bone surface resorption or osteolysis than that by UHMWPE or Co Cr Mo particles. Conclusion Various kinds of wear particles with the same size and same amount show different capability in inducing periimplant osteolysis. Osteointegration seems to be more vulnerable to UHMWPE or Co Cr Mo particles.