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目的 评价泰素、卡铂联合常规分割放疗治疗老年非小细胞肺癌的疗效及耐受性。方法 PC方案给予泰素15 0mg/m2 、卡铂 3 0 0mg/m2 静脉注射 ,间隔 2 8天为 1周期 ,重复 2～ 4个周期后给予常规分割放射治疗 (2Gy/次 ,5次 /周 ) ,照射野包括肺部原发灶和纵隔淋巴引流区 ,总剂量为 60～ 70Gy。结果 5 2例患者均完成 2个周期以上化疗及放疗 ,完全缓解 6例、部分缓解 2 6例 ,总有效率 61 5 %。化疗的毒副作用主要为骨髓抑制。放射治疗的毒性反应主要为放射性食道炎、放射性肺炎及放射性皮炎。结论 泰素、卡铂联合常规分割放疗治疗老年非小细胞肺癌近期疗效、耐受性好 ,局部控制率高 ,有望取得较好的远期疗效
Objective To evaluate the efficacy and tolerability of taxol and carboplatin combined with conventional fractionated radiotherapy in the treatment of elderly non-small cell lung cancer. Methods PC program given Paclitaxel 150mg / m2, carboplatin 300mg / m2 intravenously, an interval of 28 days for a cycle, repeated 2 to 4 cycles after conventional fractionated radiotherapy (2Gy / time, 5 times / week ), Radiation field, including the primary lung and mediastinal lymphatic drainage area, the total dose of 60 ~ 70Gy. Results All 52 patients completed more than two cycles of chemotherapy and radiotherapy, with complete remission in 6 cases and partial remission in 26 cases, with a total effective rate of 61.5%. The main side effects of chemotherapy for bone marrow suppression. Toxicity of radiation therapy is mainly radiation esophagitis, radiation pneumonitis and radiation dermatitis. Conclusion Paclitaxel and carboplatin combined with conventional fractionated radiotherapy for the treatment of elderly non-small cell lung cancer have short-term curative effect, good tolerability and high local control rate, and are expected to achieve better long-term curative effect