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目的:观察胸腔内注入顺铂(DDP)联合高聚金葡素(HASL)治疗恶性胸腔积液的疗效。方法:64例患者均经病理确诊为恶性胸腔积液,行胸腔内置管引流排尽胸液后,随机分为2组,治疗组(34例)在胸腔内注入DDP40 mg/m2,HASL 6000 U;对照组(30例)在胸腔内注入DDP 40mg/m2,两组均在1周及2周后各重复注药1次,共3次,观察疗效、生活质量、生存率以及升白细胞作用。结果:治疗组总有效率较对照组有显著性差异(P<0.05),Karnofsky评分大于70分,治疗组较对照组有显著提高(P<0.05)。治疗组0.5 a、1 a生存率较对照组有显著性差异(P<0.01)。对照组白细胞下降较治疗组明显。结论:胸腔内注入DDP 和HASL治疗恶性胸腔积液是一种有效、副反应小、可耐受的方法。
Objective: To observe the effect of intrapleural injection of cisplatin (DDP) combined with polygalacturonan (HASL) in the treatment of malignant pleural effusion. Methods: Sixty-four patients were pathologically diagnosed as malignant pleural effusion. Thoracic drainage was performed to drain the pleural fluid. The patients in the treatment group (34 cases) received intrapleural injection of DDP 40 mg / m2, HASL 6000 U ; Control group (30 cases) were injected with DDP 40mg / m2 in the thoracic cavity. Both groups were injected once or twice a week for 3 times to observe the curative effect, quality of life, survival rate and the effect of leukocyte. Results: The total effective rate in the treatment group was significantly higher than that in the control group (P <0.05). The Karnofsky score was more than 70 points. The treatment group was significantly higher than the control group (P <0.05). The treatment group 0.5 a, 1 a survival rate compared with the control group were significantly different (P <0.01). Leukopenia in the control group than the treatment group. Conclusions: Intrathoracic injection of DDP and HASL in the treatment of malignant pleural effusion is an effective, less side-effect and tolerable method.