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链霉素用于临床已经40余年,至今仍然常用于阴性菌和结核病的治疗。但过敏反应甚至休克屡见报道,并且国内外对其研究较少,为此本室进行研究,以便更好的防治。用商品链霉素和牛血清白蛋白合成链霉素——牛蛋白结合物(ST—BSA)作为抗原致敏豚鼠。过敏反应发生率为88％,其中休克率占76％,死亡占44％,而对照组为0％;ST—BSA致敏豚鼠离体回肠释放过敏介质生物效应实验证明,用抗原攻击后,肠管紧张度升高,
Streptomycin for clinical use for more than 40 years, is still commonly used in the treatment of negative bacteria and tuberculosis. However, allergic reactions are frequently reported shock, and less research at home and abroad, for this room to conduct research in order to better prevention and treatment. Guinea pigs were sensitized with streptomycin-bovine protein conjugate (ST-BSA) as an antigen using commercial streptomycin and bovine serum albumin. The incidence of anaphylaxis was 88%, of which shock rate was 76% and death rate was 44%, while the control group was 0%; ST-BSA sensitized guinea pig isolated ileum allergic medium biological effects experiments show that with the antigen attack, Tension increased,