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目的:研究血管内皮细胞生长因子(VEGF)在大肠癌中的表达及其与复发转移的关系:方法:采用免疫组化法对正常肠粘膜、良性腺瘤和大肠癌中的VEGF进行了定位观察。结果:大肠癌VEGF的表达比正常粘膜上皮及腺瘤细胞明显提高,并且与癌的复发和转移有关,在有复发转移的大肠癌组,VEGF的表达更加明显。结论:VEGF表达水平反映了肿瘤血管内皮细胞增殖、迁移和血管构建的水平,可作为肿瘤预后的一个指标。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in colorectal carcinoma and its relationship with recurrence and metastasis.Methods: Immunohistochemistry was used to detect the expression of VEGF in normal intestinal mucosa, benign adenoma and colorectal carcinoma . Results: The expression of VEGF in colorectal carcinoma was significantly higher than that in normal mucosa epithelial cells and adenoma cells, and was related to the recurrence and metastasis of carcinoma. The expression of VEGF was more obvious in colorectal carcinoma with recurrence and metastasis. Conclusion: The expression of VEGF reflects the level of tumor vascular endothelial cell proliferation, migration and angiogenesis, which can be used as an indicator of tumor prognosis.