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目的制备伊曲康唑凝胶剂,并比较其体外渗透性和大鼠在体滞留性。方法选用卡波姆-940作为基质制备伊曲康唑凝胶剂。采用Franz扩散池进行体外渗透性及大鼠在体滞留性实验。结果伊曲康唑凝胶体外渗透性很小,而大鼠在体皮肤的累积皮肤滞留量较大,且符合Ritger-Peppas模型。结论体外渗透性和大鼠在体滞留性试验表明该制剂有利于药物在大鼠皮肤内的滞留。
Objective To prepare itraconazole gel and compare its in vitro permeability and rat in vivo retention. Methods carbomer -940 as a matrix preparation of itraconazole gel. Franz diffusion cells were used for in vitro permeability and rat in vivo retention experiments. Results Itraconazole gel had little permeability in vitro, while the cumulative skin retention of rats in the body skin was larger and was in accordance with the Ritger-Peppas model. Conclusion In vitro permeability and rat in vivo retention tests show that the preparation is conducive to drug retention in rat skin.