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(1)2-乙硫醇基-4-甲基-5-乙基-6-氯代嘧啶和醇钠在醇溶液中反应,则生成它相应的乙硫醇-嘧啶-醚类。(2)2-乙硫醇-嘧啶类有下列结构:式中 X 为卤素或烷氧基。它很容易和氯互相作用,形成嘧啶一砜。(3)当2-乙磺醯-嘧啶类和醇钠及碱作用时,则嘧啶中的乙磺酰基在所有的情况下都相似于一个易于被烷氧基和羟基所置换的卤原子。然而氨和氯-乙磺酰-嘧啶反应时,则氯原子为氨基取代,而乙磺酰基仍然是不作用的。(4)叙述了两种新的合成4-甲基-5-乙基-6-氨基-2-氧-嘧啶的方法。
(1) The reaction of 2-ethanethiol-4-methyl-5-ethyl-6-chloropyrimidine and sodium alcoholate in alcoholic solution yields its corresponding ethanethiol-pyrimidine-ethers. (2) 2-ethanethiol-pyrimidines have the following structure: wherein X is halogen or alkoxy. It easily interacts with chlorine to form pyrimidine-sulfone. (3) When 2-ethylsulfanyl-pyrimidines and sodium alkoxides and bases act, then the ethanesulfonyl group in the pyrimidine is in all cases similar to a halogen atom easily displaced by alkoxy and hydroxyl groups. However, when ammonia is reacted with chloro-ethanesulfonyl-pyrimidine, the chlorine atom is replaced by an amino group and the ethanesulfonyl group is still inactive. (4) Two new methods of synthesizing 4-methyl-5-ethyl-6-amino-2-oxo-pyrimidine are described.