天王补心丸 ,安神补气丸两种浓缩丸中均含有朱砂 ,二者均为中医临床常用的安神剂 ,但朱砂含硫化汞 (ＨｇＳ) ,为有毒药物 ,药典规定用量为 0 .1～ 0 .5ｇ ,多入丸散服 ,不宜入煎剂。历代本草对朱砂毒性的认识是逐渐深入的。由《神农本草经》的“久服通神明不老” ,到《本草纲目 Tianwang Buxin Pills and Anshen Buqi Pills contain cinnabar in both concentrated pills. Both of them are commonly used in the clinical practice of traditional Chinese medicine, but cinnabar contains mercury sulfide (HgS), which is a toxic drug. The pharmacopoeia requires an amount of 0.1 to 1 0. 5g, multi-entry pills, not suitable for decoction. The understanding of cinnabar toxicity in ancient Chinese herbal medicine has gradually deepened. From the “Shannon Treasure of the Shennong Materia Medica” to the “Compendium of Materia Medica”