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目的:验证与评估诺森(注射用泮托拉唑钠)治疗上消化道出血的临床疗效和安全性。方法:采用随机分组、平行对照、多中心同步试验方法,对160例各种类型胃炎、消化性溃疡、肝硬化合并胃粘膜病变所致上消化道出血患者,分别应用诺森针剂40mg,qd,静滴3d～5d;奥美拉唑40mg,qd,静滴3d～4d,观察两组药物止血效果及不良反应。结果:诺森组与奥美拉唑组总有效率分别为96.67％与95.00％,两组间疗效无显著性差异(P>0.05);不良反应发生率分别为6.67％和6.67％,两组间无显著性差异(P>0.05),且不良反应轻微;两组病人用药前后造血功能和肝、肾功能及尿常规均无显著性变化。结论:诺森治疗上消化道出血具有较好的疗效,且无明显不良反应。
Objective: To validate and evaluate the clinical efficacy and safety of Northrop (sodium pantoprazole for injection) in the treatment of upper gastrointestinal bleeding. Methods: A total of 160 patients with various types of gastritis, peptic ulcer, liver cirrhosis complicated with gastric mucosal lesions caused by upper gastrointestinal hemorrhage were randomly divided into three groups: control group (n = 40), qd group Intravenous infusion of 3d ~ 5d; omeprazole 40mg, qd, intravenous infusion 3d ~ 4d, to observe the two groups of drugs to stop bleeding and adverse reactions. Results: The total effective rates of Northrens and Omeprazole groups were 96.67% and 95.00%, respectively, with no significant difference between the two groups (P> 0.05). The adverse reactions were 6.67% and 6.67% There was no significant difference between the two groups (P> 0.05), and the adverse reactions were mild. Before and after treatment, the hematopoietic function, liver function, renal function and urine routine did not change significantly in both groups. Conclusion: Northrend has superior efficacy in the treatment of upper gastrointestinal bleeding with no obvious adverse reactions.