特应性皮炎(atopic dermatitis，AD)是儿科常见皮肤病，是一种遗传和环境因素共同作用、与过敏素质有关的慢性炎症性皮肤病，约60%患者起病于1岁之前。随着对AD发病机制研究的不断深入，目前研究显示细胞焦亡途径中相关的炎症分子可能参与AD的发生发展。细胞焦亡是一种伴有炎症因子释放的细胞程序性死亡，已被证明在动脉粥样硬化、糖尿病、哮喘、炎症性肠病等疾病中起重要作用。该文就细胞焦亡相关的炎症分子在特应性皮炎发病中的作用作一综述，以期加深对特应性皮炎发病机制的理解并探索新的治疗策略。“,”Atopic dermatitis(AD)is a common skin disease in pediatrics.It is a chronic inflammatory skin disease related to allergic diathesis that interacts with genetic and environmental factors.In about 60% of patients, the onset is before the age of one.With the deepening of research on the pathogenesis of AD, current research shows that pyroptosis-related inflammatory molecules may be involved in the occurrence and development of AD.Pyroptosis is a kind of regulated cell death accompanied by the release of inflammatory cytokines.It has been proven to play an important role in diseases such as atherosclerosis, diabetes, asthma, and inflammatory bowel disease.This article summarizes the role of inflammatory molecules related to pyroptosis pathway in the pathogenesis of atopic dermatitis, in order to deepen the understanding of the pathogenesis of atopic dermatitis and explore new therapies for it.