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目的:探讨细胞色素P450(cytochrome P450,CYP)1A1基因MspⅠ位点多态性与鲁北地区汉族女性子宫肌瘤的关系。方法:以病例-对照的研究方法,采用PCR-RFLP方法检测了123例子宫肌瘤患者和123例匹配对照者的CYP1A1基因MspⅠ位点的基因多态性。应用Logistic回归等方法分析基因多态性与子宫肌瘤的关系。结果:(1)CYP1A1基因MspⅠ位点的基因型在子宫肌瘤组与对照组中分布的差异无统计学意义(P=0.927);(2)杂合型(T/C)和突变型(C/C)与野生型(T/T)在子宫肌瘤组与对照组的分布差异均无统计学意义(P=0.738,P=0.947);(3)合并杂合型(T/C)和突变型(C/C)与野生型(T/T)比较,在子宫肌瘤组与对照组分布的差异无统计学意义(P=0.925)。结论:CYP1A1MspⅠ等位基因多态性与鲁北地区汉族女性子宫肌瘤的易感性无显著相关性。
Objective: To investigate the relationship between the MspⅠ polymorphism of cytochrome P450 (CYP) 1A1 gene and the uterine fibroids of Han women in the Lubei area. Methods: A case-control study was performed to examine the genetic polymorphism of CYP1A1 at the Msp I site in 123 cases of uterine fibroids and 123 matched controls using PCR-RFLP. Logistic regression analysis of the relationship between gene polymorphism and uterine fibroids. Results: (1) There was no significant difference in the distribution of CYP1A1 genotypes between the two groups (P = 0.927); (2) The heterozygous (T / C) and mutant There was no significant difference in the distribution of C / C and T / T in uterine fibroid group and control group (P = 0.738, P = 0.947) (C / C) and wild type (T / T), there was no significant difference in the distribution between uterine fibroid group and control group (P = 0.925). Conclusion: CYP1A1Msp Ⅰ allele polymorphism and northern Shandong Han women with uterine fibroids no significant correlation.