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目的分析前列腺肾型透明细胞癌的病理形态、免疫组化、诊断与鉴别诊断。方法运用组织病理学、组织化学、免疫组化对1例发生于前列腺的肾型透明细胞癌进行观察,并结合文献加以分析。结果前列腺肾型透明细胞癌的瘤细胞及组织结构与肾透明细胞癌相似,细胞胞质丰富,淡染至透明,呈腺泡状、腺管状、片巢状排列。免疫组化:低分子质量角蛋白(CK-LMW)、EMA、vimentin和CD10(+),高分子质量角蛋白(CK-HMW)、广谱角蛋白(CKpan)、PAP和PSA(-)。结论前列腺肾型透明细胞癌是一种前列腺癌罕见的特殊类型,其起源尚不确定,在诊断中应该注意鉴别。
Objective To analyze the pathological morphology, immunohistochemistry, diagnosis and differential diagnosis of clear cell renal cell carcinoma of the prostate. Methods Histopathology, histochemistry and immunohistochemistry were used to examine a case of clear cell renal cell carcinoma of the kidney that was found in the prostate and analyzed by literature. Results Prostatic renal clear cell carcinoma of the tumor cells and tissue structure similar to renal clear cell carcinoma, rich in cytoplasm, pale stained to transparent, acinar, glandular tubular, nested arrangement. Immunohistochemistry: CK-LMW, EMA, vimentin and CD10 (+), CK-HMW, CKpan, PAP and PSA (-). Conclusions Prostate renal cell carcinoma is a rare special type of prostate cancer whose origin is not yet known. At diagnosis, attention should be paid to the identification.