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目的探讨原发鼻腔NK-T细胞淋巴瘤临床特征、治疗及影响预后因素。方法收集蚌埠医学院附属医院1995年1月-2003年7月收治的原发鼻腔NK-T细胞淋巴瘤57例,按照Ann Arbor分期标准,ⅠE期30例,ⅡE期21例,Ⅲ期4例,Ⅳ期2例。单纯放疗27例,放化疗30例。结果全组中位生存62个月,5年总生存率单纯放疗组、放化疗联合治疗组分别为64.0%、56.0%;中位生存期分别为64个月、61个月,差异无统计学意义(P>0.05)。分析显示,硬腭和/或鼻中隔穿孔、PS评分、发热等B症状与预后关系密切,AnnArbor分期仍然是影响生存率的主要因素(P<0.05)。结论原发鼻腔NK/T细胞淋巴瘤早期治疗是关键,放疗联合化疗未改善预后。
Objective To investigate the clinical features, treatment and prognostic factors of primary nasal NK-T cell lymphoma. Methods 57 cases of primary nasal NK-T cell lymphoma admitted from January 1995 to July 2003 in Bengbu Medical College Affiliated Hospital were enrolled. According to Ann Arbor staging criteria, there were 30 cases of stage ⅠE, 21 cases of stage ⅡE and 4 cases of stage Ⅲ , 2 cases of stage Ⅳ. Radiotherapy in 27 cases, radiotherapy and chemotherapy in 30 cases. Results The median survival time was 62 months. The 5-year overall survival rate was 64.0% and 56.0% in the radiotherapy alone group and radiotherapy and chemotherapy combined group respectively. The median survival time was 64 months and 61 months respectively, with no significant difference Significance (P> 0.05). Analysis showed that hard palate and / or nasal septum perforation, PS score, fever and other symptoms and prognosis are closely related to B, AnnArbor stage is still the main factor affecting the survival rate (P <0.05). Conclusion The early treatment of primary nasal NK / T cell lymphoma is the key, radiotherapy combined with chemotherapy did not improve the prognosis.