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Ｔ细胞的激活需要两个不可或缺的刺激信号[1] :即由Ｔ细胞受体 (ＴＣＲ)与抗原提呈细胞 (ＡＰＣ)提呈的ＭＨＣ 抗原多肽复合物相结合所产生的第一信号 (识别信号 ) ,和由ＡＰＣ表面协同刺激分子与Ｔ细胞表面对应受体分子相结合所产生的第二信号 (协同刺激信号 /激活信号 )。识
The activation of T cells requires two indispensable stimuli [1]: the first signal produced by the binding of the T cell receptor (TCR) to the antigen presenting cell (APC) presented MHC antigen polypeptide complex (Recognition signal), and a second signal (costimulatory signal / activation signal) produced by the combination of APC surface costimulatory molecules and corresponding T cell surface receptor molecules. knowledge