The on-line diameter measurement of larger axis workpieces is hard to achieve high precision detection, because of the bad environment of locale, the problem to amend the measuring error by non-uniform temperature field, and the difficulty to collimate and locate by usual method. By improving the measurement accuracy of larger axis accessories, it is useful to raise axis and hole’s industry produce level. Because of the influence of complex environment in locale and some influential factors which are hard excluded from the large diameter measurement with multi-rolling-wheels method, the measurement results may not support or even contradict each other. To the situation, this paper puts forward a mutual support deviation distinguish data fusion method, including mutual support deviation detection and weight data fusion. The mutual support deviation detection part can effectively remove or weaken the unexpected impact on the measurement results and the weight data fusion part can get more accurate estimate result to the detected data. So the method can further improve the reliability of measurement results and increase the accuracy of the measurement system. By using the weight data fusion based on the mutual support (DFMS) to the simulation and experiment data, both simulation results and experiment results show that the method can effectively distinguish the data influenced by unexpected impact and improve the stability and reliability of measurement results. The new provided mutual support deviation distinguish method can be used to single sensor measurement and multi-sensor measurement, and can be used as a reference in the data distinguish of other area. The DFMS is helpful to realize the diameter measurement expanded uncertainty in 5×10~(-6) D or even higher when the measured axis workpiece’s diameter is 1-5 m (1m≤D≤5m).