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肝硬变顽固性腹水形成的原因之一是有效循环血容量不足。肝硬变晚期肝功能失代偿严重,对肾上腺素及抗利尿激素的降解能力降低,同时伴有肾上腺素及抗利尿激素分泌增加、醛固酮增多、肾小管重吸收钠增加、尿钠分泌减少、细胞外液容量增加,使腹水加剧。因此增强肝肾功能,改善全身微循环能促进腹水的消退。现就血管活性药物在肝硬变顽固性腹水中的应用作一概述。
One of the reasons for the formation of cirrhosis and refractory ascites is the lack of effective circulating blood volume. Severe decompensation of liver function in advanced liver cirrhosis on adrenaline and vasopressin degradation ability, accompanied by increased adrenaline and antidiuretic hormone secretion, increased aldosterone, tubular reabsorption of sodium increased urinary sodium secretion decreased, Increased extracellular fluid volume, so that ascites exacerbated. Therefore, enhance liver and kidney function, improve systemic microcirculation can promote ascites. Now on the vasoactive drugs in cirrhosis and refractory ascites in the application made an overview.