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目的探讨氨基末端B型钠尿肽原(NT-proBNP)、同型半胱氨酸(Hcy)和C-反应蛋白(CRP)在急性脑血管病(CVD)诊治中的作用。方法检测88例脑出血患者(ICH)和68例脑梗死患者(CI),另选取50例正常对照组,检测血浆NT-proBNP、Hcy和CRP水平,并跟踪观察CVD患者治疗过程中NT-proBNP、Hcy和CRP水平的变化,进行统计分析。结果 CVD组患者NT-proBNP、Hcy和CRP水平较正常对照组明显升高,差异有统计学意义(P<0.01)。ICH组患者CRP水平明显高于CI组,差异有统计学意义(P<0.01),但两组间NT-proBNP和Hcy水平差异无统计学意义(P>0.05)。治疗期间病情恶化发生脑血管意外患者血浆NT-proBNP、Hcy和CRP水平明显高于未发生脑血管意外组,差异有统计学意义(P<0.01)。结论血浆NT-proBNP、Hcy和CRP的水平检测在CVD患者的诊断和治疗中具有十分重要的价值。
Objective To investigate the role of NT-proBNP, Hcy and C-reactive protein (CRP) in the diagnosis and treatment of acute cerebrovascular disease (CVD). Methods 88 patients with cerebral hemorrhage (ICH) and 68 patients with cerebral infarction (CI) were enrolled in the study. Fifty normal controls were selected to detect the plasma levels of NT-proBNP, Hcy and CRP. The levels of NT-proBNP , Hcy and CRP levels, statistical analysis. Results The levels of NT-proBNP, Hcy and CRP in CVD group were significantly higher than those in normal control group (P <0.01). The CRP level in ICH group was significantly higher than that in CI group (P <0.01), but there was no significant difference between the two groups in the level of NT-proBNP and Hcy (P> 0.05). The plasma levels of NT-proBNP, Hcy and CRP in patients with cerebrovascular accident during the course of treatment were significantly higher than those without cerebrovascular accident, the difference was statistically significant (P <0.01). Conclusion The detection of plasma NT-proBNP, Hcy and CRP levels is of great value in the diagnosis and treatment of CVD patients.