许多研究证明,前列腺素(PG),尤其是PGE对接触各种致坏死因素的胃、十二指肠、小肠粘膜有细胞保护作用,而非甾体抗炎药如阿斯匹林、消炎痛、Ibuprofen则被认为通过抑制内源性PG的合成,损伤胃粘膜而造成刺激、溃疡和出血。然而,文献中的一些例子表明在某些情况下PG对胃肠道粘膜有损伤作用,而非甾体抗炎药则对此有保护作用。 Many studies have shown that prostaglandins (PGs), especially PGE, have cytoprotective effects on the stomach, duodenum and small intestine in contact with various necrotic factors, while non-steroidal anti-inflammatory drugs such as aspirin, indomethacin , Ibuprofen is thought to cause irritation, ulceration and bleeding by damaging the gastric mucosa by inhibiting the synthesis of endogenous PG. However, some examples in the literature suggest that PG may have an adverse effect on the gastrointestinal mucosa in some cases, whereas non-steroidal anti-inflammatory drugs may have protective effects.