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以叶绿素降解产物脱镁叶绿酸-a甲酯为起始原料,利用其二氢卟吩大环上的活性反应区域,沿着N21-N23轴向进行官能团修饰,通过1,3-偶极环加成反应、Grignard反应和外接环的结构改造,在周环上的不同位置上引进了三元环烷基结构,完成了一系列未见报道的叶绿素类二氢卟吩衍生物的合成,其化学结构均经UV,IR,1H NMR,MS及元素分析予以证实,同时也讨论了环丙基的引进对二氢卟吩的理化性质所产生的各种影响,并对部分新化合物的体外光动力活性进行了测试.
Chlorophyll degradation products pheophorbide-a methyl ester as a starting material, using its chlorin macrocyclic active reaction region along the axis of N21-N23 functional groups modified by 1,3 dipole Cycloaddition reaction, Grignard reaction and the structural modification of the external ring, the introduction of a three-membered cycloalkyl structure at different positions on the pericyclic ring completed a series of previously reported synthesis of chlorophyll-type chlorin derivatives, Their chemical structures were confirmed by UV, IR, 1H NMR, MS and elemental analysis. The effects of cyclopropyl on the physical and chemical properties of chlorin were also discussed. Some of the new compounds were studied in vitro Photodynamic activity was tested.