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目的探讨亮丙瑞林治疗后血清黄体生成素(LH)水平评估中枢性性早熟(CPP)患儿治疗效果的价值。方法女性CPP患儿16例,采用亮丙瑞林3.75mg治疗,每4周注射1次。分别于治疗前及治疗12、24周时检测注射后2h血清LH水平,结合生长发育、子宫B超及骨龄X射线片等指标综合评估疗效。结果与治疗前比较,治疗12周患儿乳房、卵巢、子宫等性腺发育呈减缓趋势,治疗24周发育进一步减缓(P<0.05),且骨龄/年龄比值降低,预测的成年期身高增加(P<0.05)。治疗12周和24周时的血清LH水平相仿(P>0.05),但均低于治疗前(P<0.05)。结论亮丙瑞林注射后2h,血清LH水平≤5.6IU/L,提示CPP患儿治疗效果较好。
Objective To investigate the value of serum luteinizing hormone (LH) after leuprorelin treatment in the treatment of central precocious puberty (CPP) in children. Methods 16 females with CPP were treated with 3.75 mg of leuprolide and injected once every 4 weeks. The levels of serum LH were measured 2h after injection and before and 12,24 weeks of treatment, respectively. Combined with the indexes of growth and development, uterine B ultrasound and bone age X-ray, the curative effect was evaluated comprehensively. Results Compared with those before treatment, gonadal development in breast, ovary and uterus of the 12-week-old children showed a trend of slowing down. The development of the gonad decreased further at 24 weeks of treatment (P <0.05), and the bone age / age ratio decreased. <0.05). Serum LH levels at 12 weeks and 24 weeks after treatment were similar (P> 0.05), but both were lower than before treatment (P <0.05). Conclusions 2 h after injection of leuprolide, the serum LH level is less than or equal to 5.6 IU / L, suggesting that the treatment effect of CPP children is better.