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研究新疆不同民族食管癌组织内ｐ１６、Ｒｂ蛋白表达与其生物学行为的关系。方法：应用免疫组化链霉蛋白－过氧化物酶连接法（ＬＳＡＢ法）检测１１９例不同民族食管癌ｐ１６、Ｒｂ蛋白表达。结果：新疆食管癌１６蛋白的阳性检出率为５７．９％， Ｒｂ蛋白阳性检出率为４１．２％，二者在民族间的阳性表达率均无显著性差异（Ｐ＞ ０．０５）。随着恶性程度增加及病程进展，ｐ１６蛋白阳性率逐渐下降，Ｒｂ蛋白阳性率逐渐上升，但未发现二者呈负相关关系（Ｐ＞０．０５）。ｐ１６、Ｒｂ蛋白阳性均与组织学分级无关（Ｐ＞ ０．０５）；ｐ１６蛋白阳性与肿瘤浸润深度以及淋巴结转移有关（Ｐ ＜０．０５），而Ｒｂ蛋白阳性与肿瘤浸润深度无关（Ｐ＞ ０．０５），与淋巴结转移有关（Ｐ＜０．０５）。结论：食管癌组织内ｐ１６、 Ｒｂ蛋白表达在新疆不同民族之间无显著性差异；检测ｐ１６、Ｒｂ蛋白表达的情况有助于判断食管癌的恶性程度以及推断临床预后。
To study the relationship between p16 and Rb protein expression and biological behavior in esophageal cancer tissues from different ethnic groups in Xinjiang. Methods: The expression of p16 and Rb proteins in 119 cases of esophageal cancer of different ethnicities was detected by immunohistochemical streptavidin-peroxidase ligation (LSAB) method. Results: The positive detection rate of 16 protein in esophageal cancer in Xinjiang was 57.9%, and the positive rate of Rb protein was 41.2%. There was no significant difference in positive expression rate between the two groups (P> 0.05). ). With the increase of malignancy and progression of disease, the positive rate of p16 protein gradually decreased, and the positive rate of Rb protein increased gradually, but no negative correlation was found (P>0.05). The positive rates of p16 and Rb proteins were not related to the histological grade (P> 0.05). The positive rate of p16 protein was related to the depth of tumor invasion and lymph node metastasis (P <0.05), but the positive rate of Rb protein was not related to the depth of tumor invasion (P> 0.05) was associated with lymph node metastasis (P<0.05). Conclusion: The expression of p16 and Rb protein in esophageal cancer tissue has no significant difference among different ethnic groups in Xinjiang; detecting the expression of p16 and Rb protein is helpful to determine the degree of malignancy of esophageal cancer and infer clinical prognosis.