缺血性血管疾病包括冠心病和外周血管闭塞性疾病已成为发达国家及许多发展中国家的主要疾病之一。血管重建 (即血管新生、血管生成及动脉生成 )是机体在血管闭塞状态下的病理生理性代偿反应。以改善缺血为目的 ,应用促血管因子、基因治疗和血管祖细胞补充治疗已成为当前缺血性血管疾病治疗的研究热点。 Ischemic vascular diseases, including coronary heart disease and peripheral vascular occlusive disease, have become one of the major diseases in both developed and many developing countries. Vascular remodeling (ie, angiogenesis, angiogenesis, and arteriogenesis) is a pathophysiologic compensatory response of the body in the state of vascular occlusion. In order to improve ischemia, the application of pro-angiogenic factors, gene therapy and vascular progenitor cell replacement therapy has become the current hot spot in the treatment of ischemic vascular diseases.