一、概述含小蘖碱的中草药用干临床已有几千年的历史了,《神农本草》就有记载。我国已发现含小蘖碱的中草药分属于植物学中的四个科,十个属,品种多、资源丰富,成为近年生产小蘖碱的原料。自1957年始,即大规模地生产小蘖碱的盐类,并广泛用于临床。其后又从含小蘖碱植物(三颗钎、十大功劳等)中分离出了多种生物碱,除小蘖碱外,主要还有:药根碱(Jatrorrhizine),巴马叮(Palmatine),咖伦明(Colum- I. Overview The use of berberine in Chinese herbal medicine has been clinically used for thousands of years, and it has been recorded in Shennong Materia Medica. China has found that berberine-containing Chinese herbal medicines belong to the four branches of botany, ten genera, many varieties, rich in resources, has become the raw material for the production of berberine in recent years. Since 1957, berberine salts have been produced on a large scale and are widely used clinically. Afterwards, a number of alkaloids were isolated from berberine-containing plants (three brazes, madam, etc.). In addition to berberine, there were mainly jatrorrhizine and palmatine. ),Colum-