急性肾功能衰竭(ARF)可由于缺血、创伤、中毒、感染等多种原因引起,是人类常见的死亡原因之一。目前的预防和治疗方法较多,如利尿剂、血管扩张剂、高渗糖、中药等等,但都只能在开始期应用才有一定效果。一旦ARF已确立而需要行透析时,其死亡率高达50％以上。为此,寻求一种在肾缺血后期对肾脏功能和细胞仍有保护作用的治疗方法是十分需要的。近来在ARF病理生理的研究中发现,在ARF时首先发生的是组织的代 Acute renal failure (ARF) may be caused by a variety of reasons such as ischemia, trauma, poisoning and infection and is one of the common causes of death in humans. The current prevention and treatment methods are more, such as diuretics, vasodilators, hypertonic sugar, traditional Chinese medicine, etc., but only in the initial application have some effect. Once ARF has been established and needs dialysis, the mortality rate is as high as 50%. For this reason, it is very necessary to seek a treatment method that still has a protective effect on renal function and cells in the late stage of renal ischemia. Recently in the pathophysiology of ARF study found that the first in the ARF occurs when the organization’s behalf