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目的：探讨氧化与抗氧化在糖尿病肾病发生发展中的作用。方法：测定对照（Ｃ）组１５人及糖尿病蛋白尿正常（ＤＭⅠ）组、微量白蛋白尿（ＤＭⅡ）组、临床蛋白尿（ＤＭⅢ）组患者共５６例的红细胞铜，锌超氧化物歧化酶（ＳＯＤ）及血清维生素（ＶｉｔＣ）。结果：ＳＯＤ与尿白蛋白排泄率（ＵＡＥＲ）呈明显负相关，ＤＭⅡ组明显高于Ｃ、ＤＭⅠ组，低于ＤＭⅢ组（Ｐ＜０．０１）；ＶｉｔＣ与ＵＡＥＲ呈明显负相关（Ｐ＜０．０１），但ＤＭⅠ与Ⅱ组，ＤＭⅡ、Ⅲ组间Ｐ＞０．０５；ＳＯＤ、ＶｉｔＣ与ＨｂＡ１Ｃ间呈负相关，前者Ｐ＜０．０１，后者Ｐ＞０．０５。结论：抗氧化能力下降可能是糖尿病发生肾脏损伤的原因之一，并可反映损伤程度。
Objective: To investigate the role of oxidation and antioxidation in the development of diabetic nephropathy. Methods: Fifty-five patients in control group (C) and 56 patients in control group (DMⅠ), microalbuminuria group (DMⅡ) and clinical proteinuria group (DMⅢ) were enrolled in this study. Erythrocyte copper, zinc superoxide dismutase (SOD) and serum vitamins (VitC). Results: There was a negative correlation between SOD and urinary albumin excretion rate (UAER), DM Ⅱ group was significantly higher than C, DM Ⅰ group, lower than DM Ⅲ group (P <0.01); VitC and UAER was negatively correlated .01), but there was a negative correlation between SOD, VitC and HbA1C in DMⅠandⅡ, DMⅡandⅢgroup (P <0.01, P <0.05). Conclusion: Decreased antioxidant capacity may be one of the causes of kidney damage in diabetes, and may reflect the degree of injury.