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目的:探讨吉兰-巴雷综合征(GBS)相关性肺炎的危险因素及病原学特点。方法:收集160例GBS合并肺炎患者(观察组)及164例无肺炎的GBS患者(对照组)的临床资料,分析GBS合并肺炎的危险因素。结果:GBS合并肺炎组中年龄、变异型GBS、慢性阻塞性肺病、吞咽困难、气管切开、使用呼吸机、使用质子泵抑制剂、未应用免疫球蛋白、肌电图有脱髓鞘合并轴索损伤表现、住院天数均高于对照组(P<0.05),Logistic回归分析表明年龄、变异型GBS、慢性阻塞性肺病、吞咽困难、气管切开、使用呼吸机、使用质子泵抑制剂、未应用免疫球蛋白是GBS合并肺炎的独立危险因素(P<0.05)。共检出有效菌株124株,其中革兰阴性杆菌71.8%,革兰阳性球菌28.2%。结论:年龄、变异型GBS、慢性阻塞性肺病、吞咽困难、气管切开、使用呼吸机、使用质子泵抑制剂、未应用免疫球蛋白是GBS合并肺炎的独立危险因素,GBS合并肺炎患者的主要致病菌为革兰阴性杆菌。
Objective: To investigate the risk factors and etiological characteristics of Guillain-Barre syndrome (GBS) -related pneumonia. Methods: The clinical data of 160 patients with GBS combined with pneumonia (observation group) and 164 patients without pneumonia (control group) were collected to analyze the risk factors of GBS complicated with pneumonia. Results: GBS combined pneumonia group age, variant GBS, chronic obstructive pulmonary disease, dysphagia, tracheotomy, the use of ventilator, the use of proton pump inhibitors, not the application of immunoglobulin, electromyography demyelination axis (P <0.05). Logistic regression analysis showed that age, variant GBS, chronic obstructive pulmonary disease, dysphagia, tracheotomy, use of ventilator, use of proton pump inhibitor, The use of immunoglobulins was an independent risk factor for GBS with pneumonia (P <0.05). A total of 124 effective strains were detected, of which 71.8% were Gram-negative bacilli and 28.2% were Gram-positive cocci. CONCLUSIONS: Age, variant GBS, chronic obstructive pulmonary disease, dysphagia, tracheotomy, the use of ventilators, the use of proton pump inhibitors, and the lack of use of immunoglobulins were independent risk factors for GBS with pneumonia and GBS with pneumonia Pathogenic bacteria Gram-negative bacilli.