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目的 观察顺铂联合足叶乙甙、α—干扰素治疗恶性胸腔积液疗效。方法 恶性胸水43例经胸腔闭塞引流及胸腔穿刺抽液后胸腔内注射顺铂、足叶乙甙及α—干扰素观察胸水的变化及毒副作用。结果 根据WHO癌性渗液的疗效评定标准,完全缓解21例(48.8％),部分缓解17例(39.2％),总有效率88％。结论 顺铂联合足叶乙甙、α—干扰素胸腔内注射治疗恶性胸腔积液能够相互协同作用,明显提高疗效,是一种安全有效的方法。
Objective To observe the efficacy of cisplatin combined with acetochlor and α-interferon in the treatment of malignant pleural effusion. Methods The changes of pleural effusion and toxic side effects were observed in 43 patients with malignant pleural effusion treated with intrathoracic injection of cisplatin, etoposide, and α-interferon after chest cavity occlusive drainage and thoracentesis. Results According to the evaluation criteria of efficacy of cancerous effusion in WHO, 21 cases (48.8%) were completely relieved, and 17 cases (39.2%) were partially relieved. The total effective rate was 88%. Conclusion The combination of cisplatin with acetoside and interferon α-interferon for the treatment of malignant pleural effusion can work synergistically to improve the efficacy, which is a safe and effective method.