论文部分内容阅读
目的评价莫西沙星在治疗老年慢性阻塞性肺疾病急性发作(AECOPD)的近期和远期疗效。方法将140例老年AECOPD患者随机分为两组,治疗组(68例)予莫西沙星0.4g(每日一次),静脉滴注;对照组(72例)予头孢曲松钠2.0g(每日一次),静脉滴注,两组疗程均为7～14d,观察临床总有效率、细菌清除率及再发间隔时间。结果治疗组临床总有效率为88.2%,细菌清除率为93.1%,再发间隔时间为110.4d;对照组临床总有效率为75.0%,细菌清除率为71.9%,再发间隔时间为91.4d。两组比较,差异均有统计学意义(均P<0.05)。结论莫西沙星治疗老年AECOPD临床疗效肯定,可减少AECOPD发作频率。
Objective To evaluate the short-term and long-term effects of moxifloxacin in the treatment of acute exacerbation of senile chronic obstructive pulmonary disease (AECOPD). Methods A total of 140 elderly AECOPD patients were randomly divided into two groups. The treatment group (68 patients) received moxifloxacin 0.4g (once daily), and the control group (72 patients) received ceftriaxone 2.0g Day), intravenous drip, two courses of treatment were 7 ~ 14d, observe the total effective rate of the bacteria, bacterial clearance and recurrence interval. Results The total effective rate of the treatment group was 88.2%, the bacterial clearance rate was 93.1% and the recurrence interval was 110.4 days. In the control group, the total effective rate was 75.0%, the bacterial clearance rate was 71.9% and the recurrence interval was 91.4 days . The differences between the two groups were statistically significant (both P <0.05). Conclusion Moxifloxacin treatment of senile AECOPD clinical efficacy can reduce the frequency of AECOPD seizure.