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[目的]对7例骨原发性恶性淋巴瘤（PLB）进行临床病理、免疫组化研究，以探讨其在诊断及鉴别诊断上的意义。[方法]标本采用常现石蜡切片、HE染色及ABC法免疫级化染色，光镜观察。[结果]患者以男性多见（6/7例），好发于扁骨。多数为B细胞性淋巴瘤（5／7例），T细胞性淋巴瘤（1/7例）和组织细胞性淋巴瘤（1／7例）少见。免疫组化染色7例瘤细胞均表达LCA阳性，其中5例表达126阳性，1例UCHL1阳性，1例MAC387阳性。（结论）PLB较罕见，多为B细胞性。其起源可能与骨髓内B淋巴细胞恶变有关。其应与骨内其它原发性或继发性小细胞性恶性肿瘤相鉴别，免疫组化染色对骨PLB诊断、分型及鉴别论断均有重要的意义。
[Objective] To study the clinicopathological and immunohistochemical study of 7 cases of primary malignant lymphoma of the bone (PLB) to explore its significance in diagnosis and differential diagnosis. [Methods] The specimens were stained with paraffin wax, stained with HE and stained with ABC. The specimens were observed under light microscope. [Results] Patients were more common in males (6/7 cases) and occurred in flat bones. Most of them are B-cell lymphomas (5/7 cases). T-cell lymphomas (1/7 cases) and histiocytic lymphomas (1/7 cases) are rare. Immunohistochemical staining of 7 cases of tumor cells expressed LCA positive, of which 5 cases expressed 126 positive, 1 case of UCHL1 positive, 1 case of MAC387 positive. (Conclusion) PLB is rare and mostly B-cell. Its origin may be related to the malignant transformation of B lymphocytes in the bone marrow. It should be differentiated from other primary or secondary small cell malignant tumors in bone. Immunohistochemical staining is of great significance in the diagnosis, classification, and differentiation of bone PLB.