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作者以前对恒河猴的研究表明,从皮下胆固醇丸中,持续给予D-色~6-LHRH乙基酰胺可抑制排卵,并使血浆LH水平陡降至检出极限以下。作者近来在恒河猴中,应用更为有效的显效剂D-Nal(2)~6LHRH每天给药一次,已证实排卵的抑制与剂量有关。5μg/天是抑制排卵的最低有效剂量。每次注射5μg后,血浆LH急剧升高,但在每次注射前测得的LH基础水平,完全在治疗前的范围内。为了明确上述LH反应的差异是由于化合物不同还是剂量不同所致,作者以一种能生物降解的聚乳酸-羟基乙酸微胶囊的形式,持续给予D-Nal(2)~6
Previous studies of rhesus monkeys by the authors showed that continuous administration of D-6H-LHRH ethylamide inhibits ovulation and subsides plasma LH levels below the detection limit from subcutaneous cholesterol pellets. Recently, in the rhesus monkeys, the more effective effective agent D-Nal (2) ~ 6LHRH was administered once a day. The inhibition of ovulation has been proved to be dose-dependent. 5μg / day is the lowest effective dose to inhibit ovulation. After each injection of 5 μg, the plasma LH increased sharply, but the basal level of LH measured before each injection was completely within the pre-treatment range. To clarify whether the difference in LH response is due to different compounds or different dosages, the authors administered D-Nal (2) - 6 as a biodegradable poly (DL-lactic-co-glycolic acid)