最近,随着饮食生活等生活习惯的欧美化、人口老龄化以及由于幽门螺杆菌(Hp)感染率减低,日本的GERD呈现增加趋势。GERD的病情表现极为复杂多样,以致确立明确的治疗目标决非容易。在日本发病占多的NERD和轻症GERD确有自然治愈的病例,但也不乏需作维持治疗以控制病情者。对于内科治疗久治不愈的GERD,必须认真探讨其外科治疗的适应证。必须依据患者病型并结合具体病情,以提升病人QOL为首要目标来选择最适当的疗法。 Recently, GERD in Japan has been on the rise with the advent of European and American habits such as eating habits, the aging of the population, and the reduction of the prevalence of Helicobacter pylori (Hp) in Japan. The performance of GERD is extremely complex and diverse, so setting clear treatment goals is by no means easy. Naturally curable cases of NERD and mild GERD, which are predominant in Japan, do exist, but there is also a need for maintenance treatment to control the condition. For medical treatment of long-lasting GERD, we must seriously explore the indications for surgical treatment. Must be based on the patient’s disease type and combination of specific conditions, to enhance patient QOL as the primary goal to choose the most appropriate therapy.