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目的探讨职业性慢性镉中毒肾早期损害指标,为及时发现镉中毒提供科学依据。方法回顾分析湖南省职业病防治院收治的59名职业性慢性轻度镉中毒患者的临床资料,分别对尿镉、工龄与尿视黄醇结合蛋白、尿β2微球蛋白之间关联进行综合分析。结果尿镉与尿视黄醇结合蛋白之间无相关性(P>0.05),工龄与肾早期损害指标之间无相关性(P>0.05),但尿镉与尿β2微球蛋白存在剂量效应曲线(P<0.05),镉中毒患者,尿视黄醇结合蛋白的敏感性要高于尿β2微球蛋白(P<0.05)。结论工龄长短与肾早期损害指标之间无直线相关关系,尿β2微球蛋白水平随着尿镉浓度的增高而增高。
Objective To investigate the indicators of early renal damage in chronic occupational chronic cadmium poisoning and to provide a scientific basis for timely detection of cadmium poisoning. Methods The clinical data of 59 occupational chronic mild cadmium poisoning patients admitted to Hunan Occupational Disease Prevention and Treatment Hospital were retrospectively analyzed. The correlations between urinary cadmium, length of service, urinary retinol binding protein and urinary β2 microglobulin were analyzed respectively. Results There was no correlation between urinary cadmium and urinary retinol binding protein (P> 0.05), and there was no correlation between length of service and indicators of early renal damage (P> 0.05). However, there was dose-effect of urinary cadmium and urine β2 microglobulin (P <0.05). The sensitivity of cadmium poisoning patients and urinal retinol binding protein was higher than that of urine β2 microglobulin (P <0.05). Conclusion There is no linear relationship between the length of service and the indicators of early renal damage. Urine β2 microglobulin level increases with the increase of urinary cadmium concentration.