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采用多种细胞因子作用于人脐静脉内皮细胞（ＨＵＶＥＣ），测其ＩＬ－６的分泌。结果表明，ＩＦＮ－γ既可单独诱导又可协同促进ＴＮＦ－α诱导ＨＵＶＥＣ分泌ＩＬ－６。协同诱导的动力学表明，４ｈ后ＩＬ－６分泌明显提高。ＩＬ－１ｒａ对ＩＬ－１诱导的ＩＬ－６分泌具有抑制作用，而对ＬＰＳ诱导的ＩＬ－６分泌无影响。ＩＬ－１０可单独诱导ＨＵＶＥＣ分泌ＩＬ－６，并协同促进ＩＬ－１诱导的ＨＵＶＥＣ分泌ＩＬ－６。
Using a variety of cytokines on human umbilical vein endothelial cells (HUVEC), measured IL-6 secretion. The results showed that IFN-γcan both induce IL-6 secretion by HUVECs either alone or in combination with TNF-α. The kinetics of synergistic induction showed that IL-6 secretion increased significantly after 4 hours. IL-1ra has an inhibitory effect on IL-1-induced IL-6 secretion but has no effect on LPS-induced IL-6 secretion. IL-10 alone induces the secretion of IL-6 by HUVECs and synergistically promotes the secretion of IL-6 by HUVECs induced by IL-1.