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为探讨血管紧张素转化酶抑制剂苯那普利对不同时期慢性肾功能衰竭肾小球硬化进程的延缓作用 ,采用实验性慢性肾功能衰竭大鼠模型 ,将 40只大鼠分为正常对照组 (N组 ,10只 )、慢性肾衰疾病组 (D组 ,10只 )、苯那普利早期治疗组 (ET组 ,10只 )及苯那普利晚期治疗组 (L T组 ,10只 ) ,检测各组大鼠的血尿素氮、血肌酐、2 4h尿蛋白排泄率、平均动脉压以及肾小球平均截面积和平均体积。结果显示 ET组大鼠血尿素氮、血肌酐、2 4h尿蛋白排泄率、以及肾小球平均截面积和平均体积均显著低于 D组和 L T组 (P <0 .0 5 ) ;L T组前三项指标水平也较 D组明显下降 (P <0 .0 5 ) ,而平均动脉压、肾小球平均截面积和平均体积虽较 D组有所下降 ,但差异无显著性。提示 :早期给予苯那普利治疗能有效延缓慢性肾衰肾小球硬化的进程 ,而晚期给予苯那普利治疗虽能一定程度地改善肾功能和蛋白尿 ,但对慢性肾衰肾小球硬化的进程并无明显延缓作用
In order to investigate the effect of benazepril, an angiotensin converting enzyme inhibitor, on the progression of glomerulosclerosis in chronic renal failure in different periods, 40 rats were divided into normal control group (N = 10), chronic renal failure (group D, n = 10), early benazepril treatment group (ET group, n = 10) and benazepril late treatment group (n = 10) Blood urea nitrogen, serum creatinine, urinary protein excretion rate at 24 hours, mean arterial pressure and mean glomerular cross-sectional area and average volume of each group were measured. The results showed that the blood urea nitrogen, serum creatinine, 24 h urinary protein excretion rate, average glomerular cross-sectional area and average volume of ET group were significantly lower than those of D group and LT group (P <0.05); ET group The first three indexes also decreased significantly compared with D group (P <0.05), while mean arterial pressure, average glomerular cross-sectional area and average volume decreased compared with D group, but the difference was not significant. Tip: early give benazepril treatment can effectively delay the progression of glomerulosclerosis in patients with chronic renal failure, while the late give benazepril treatment may be able to some extent improve renal function and proteinuria, but chronic renal failure glomerular The hardening process did not have a significant retardation effect