近廿年间,随着脑膜炎病原体的变化和实验性脑膜炎模型的新抗生素应用研究,对脑膜炎的抗生素疗法也作了相应更改。作者在本文中主要讨论治疗婴幼儿脑膜炎的新进展。作者分析了1969～1982年美国达拉斯某医院和儿童医学中心的1,821例脑膜炎的病原体组成及病死率。其中流感杆菌占57%,脑膜炎双球菌占12%,肺炎球菌占8%,B群链球菌占7%,大肠杆菌类占4.1%,李司忒氏菌占0.8%。其病死率则按次为4.6%、 Nearly 20 years, with the change of meningitis pathogens and experimental application of new antibiotics in meningitis model, antibiotic therapy of meningitis has also been made corresponding changes. The author in this article focuses on the treatment of infant meningitis new progress. The authors analyzed the pathogen composition and mortality of 1,821 meningitis patients at a Dallas hospital and children’s medical center from 1969 to 1982. Among them, influenza bacilli accounted for 57%, meningococcus 12%, pneumococcus 8%, group B streptococcus 7%, E. coli 4.1% and Listeria 0.8%. The case fatality rate was followed by 4.6%