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已知18-三体胎儿与妊娠中期母体血清低甲胎蛋白(AFP)水平有关。分析14例18-三体妊娠中期母体血清 AFP、β-人绒毛膜促性腺激素(β-hCG)及未结合型雌三醇(uE_3) 水平,并与正常单胎妊娠相比较。14例18-三体妊娠中的13例是根椐 AFP、β-hCG 及 uE_3水平从5万例女性的普查中得到,其中9例经腹壁羊膜腔穿刺确诊,4例分娩18-三体胎儿。另1例是从对3000例女性的前瞻性普查中得到。
It is known that the 18-trisomy is associated with lower serum alpha-fetoprotein (AFP) levels in the second trimester of pregnancy. The levels of AFP, β-human chorionic gonadotropin (β-hCG) and unconjugated estriol (uE_3) in 14 pregnant women with 18-trisomy were analyzed and compared with normal singleton pregnancies. Thirteen of the 14 18-trisomic pregnancies were obtained from the census of 50,000 women, including 9 for the AFP, β-hCG and uE_3 levels, 9 of whom were confirmed by amniocentesis and 4 of 18 . The other case was obtained from a prospective census of 3000 women.