The sub-regions are divided for the seismicity of the Chinese mainland based on the hypothesis of the active crustal blocks and the division of the active boundaries. On this result, the seismicity of each active crustal blocks are studied by calculating the accumulated and released strain of the earthquakes based on strain accumulating and releasing model, and the different seismicity stages of the sub-regions are discussed basically. Finally we have discussed the premise of the model application and the potential problems of the model results. The sub-regions are divided for the seismicity of the Chinese mainland based on the hypothesis of the active crustal blocks and the division of the active boundaries. On this result, the seismicity of each active crustal blocks are studied by calculating the accumulated and released strain of the earthquakes based on strain accumulating and releasing model, and the different seismicity stages of the sub-regions are about basically. Finally we have discussed the premise of the model application and the potential problems of the model results.